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1

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Ward, Richard A., Anderton, Mark J., Ashton, Susan, Bethel, Paul A., Box, Matthew, Butterworth, Sam, Colclough, Nicola, Chorley, Christopher G., Chuaqui, Claudio, Cross, Darren A. E., Dakin, Les A., D

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

2

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines

Catherine Bardelle, Darren Cross, Sara Davenport, Jason G. Kettle, Eun Jung Ko, Andrew G. Leach, Andrew Mortlock, Jon Read, Nicola J. Roberts, Peter Robins, Emma J. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 356 KB

english, 2008

3

Control of ruthenium oxide nanorod length in reactive sputtering

Cross, Michael W, Varhue, Walter J, Hitt, Darren L, Adams, Edward

Journal:

Year:

2008

Language:

english

File:

PDF, 895 KB

english, 2008

4

OA10.01 Comprehensive Genomic Profiling and PDX Modeling of EGFR Exon 20 Insertions: Evidence for Osimertinib Based Dual EGFR Blockade

Riess, Jonathan, Gandara, David R., Frampton, Garrett, Cheng, Mingshan, Lara, Primo, Kelly, Karen, Ye, Chunting, Madison, Russell, Peled, Nir, Bufill, Jose, Dy, Grace, Ou, Sai-Hong, Cross, Darren, Bul

Journal:

Journal of Thoracic Oncology

Year:

2017

Language:

english

File:

PDF, 175 KB

english, 2017

5

ChemInform Abstract: Inhibitors of the Tyrosine Kinase EphB4. Part 3. Identification of Non-benzodioxole-Based Kinase Inhibitors.

Catherine Bardelle, Bernard Barlaam, Nigel Brooks, Tanya Coleman, Darren Cross, Richard Ducray, Isabelle Green, Christine Lambert-van der Brempt, Annie Olivier, Jon Read

Journal:

Year:

2011

File:

PDF, 22 KB

2011

6

Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, David G. Acton, Peter Ballard, Robert H. Bradbury, Darren Cross, Richard Ducray, Hervé Germain, Kevin Hudson, Teresa Klinowska, Françoise Magnien, Donald J. Ogilvie, Annie Olivier, He

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

7

Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines

Catherine Bardelle, Tanya Coleman, Darren Cross, Sara Davenport, Jason G. Kettle, Eun Jung Ko, Andrew G. Leach, Andrew Mortlock, Jon Read, Nicola J. Roberts, Peter Robins, Emma J. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 348 KB

english, 2008

8

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

Catherine Bardelle, Bernard Barlaam, Nigel Brooks, Tanya Coleman, Darren Cross, Richard Ducray, Isabelle Green, Christine Lambert-van der Brempt, Annie Olivier, Jon Read

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 478 KB

english, 2010

9

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

Bernard Barlaam, Richard Ducray, Christine Lambert-van der Brempt, Patrick Plé, Catherine Bardelle, Nigel Brooks, Tanya Coleman, Darren Cross, Jason G. Kettle, Jon Read

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 353 KB

english, 2011

10

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

Matthew P Coghlan, Ainsley A Culbert, Darren AE Cross, Stacey L Corcoran, John W Yates, Nigel J Pearce, Oliver L Rausch, Gregory J Murphy, Paul S Carter, Lynne Roxbee Cox, David Mills, Murray J Brown,

Journal:

Chemistry & Biology

Year:

2000

Language:

english

File:

PDF, 384 KB

english, 2000

11

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

Darren A. E. Cross, Ainsley A. Culbert, Katy A. Chalmers, Laura Facci, Stephen D. Skaper, Alastair D. Reith

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 745 KB

english, 2001

12

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, Darren A. E., Alessi, Dario R., Cohen, Philip, Andjelkovich, Mirjana, Hemmings, Brian A.

Journal:

Year:

1995

File:

PDF, 959 KB

1995

13

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK

Hall-Jackson, Clare A, Cross, Darren AE, Morrice, Nick, Smythe, Carl

Journal:

Year:

1999

Language:

english

File:

PDF, 313 KB

english, 1999

14

Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 2

Bénédicte Delouvrié, Katherine Al-Kadhimi, Jean-Claude Arnould, Simon T. Barry, Darren A.E. Cross, Myriam Didelot, Paul R. Gavine, Hervé Germain, Craig S. Harris, Adina M. Hughes, David A. Jude, Jane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 830 KB

english, 2012

15

Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 1

Bénédicte Delouvrié, Katherine Al-Kadhimi, Jean-Claude Arnould, Simon T. Barry, Darren A.E. Cross, Myriam Didelot, Paul R. Gavine, Hervé Germain, Craig S. Harris, Adina M. Hughes, David A. Jude, Jane

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.36 MB

english, 2012

16

PD 98059 Prevents Establishment of the Spindle Assembly Checkpoint and Inhibits the G2-M Transition in Meiotic but Not Mitotic Cell Cycles inXenopus

Darren A.E Cross, Carl Smythe

Journal:

Experimental Cell Research

Year:

1998

Language:

english

File:

PDF, 959 KB

english, 1998

17

GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β-catenin stabilisation without elevation of glycogen synthase activity

Ainsley A. Culbert, Murray J. Brown, Sheelagh Frame, Thilo Hagen, Darren A.E. Cross, Benjamin Bax, Alastair D. Reith

Journal:

Year:

2001

Language:

english

File:

PDF, 255 KB

english, 2001

18

The catalytic activity of cytochrome P450cam towards styrene oxidation is increased by site-specific mutagenesis

Darren P Nickerson, Charles F Harford-Cross, Sarah R Fulcher, Luet-Lok Wong

Journal:

Year:

1997

Language:

english

File:

PDF, 280 KB

english, 1997

19

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

Darren A.E. Cross, Peter W. Watt, Morag Shaw, Jeroen van der Kaay, C.Peter Downes, Julie C. Holder, Philip Cohen

Journal:

Year:

1997

Language:

english

File:

PDF, 541 KB

english, 1997

20

PDK1, one of the missing links in insulin signal transduction?

Philip Cohen, Dario R Alessi, Darren A.E Cross

Journal:

Year:

1997

Language:

english

File:

PDF, 839 KB

english, 1997

21

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Sommer, Eeva M., Dry, Hannah, Cross, Darren, Guichard, Sylvie, Davies, Barry R., Alessi, Dario R.

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 1.90 MB

english, 2013

22

A MEMS-Based Catalytic Microreactor for a H$_{\bf 2}$O$_{\bf 2}$ Monopropellant Micropropulsion System

Widdis, Stephen J., Asante, Kofi, Hitt, Darren L., Cross, Michael W., Varhue, Walter J., McDevitt, M. Ryan

Journal:

IEEE/ASME Transactions on Mechatronics

Year:

2013

Language:

english

File:

PDF, 996 KB

english, 2013

23

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Bago, Ruzica, Malik, Nazma, Munson, Michael J., Prescott, Alan R., Davies, Paul, Sommer, Eeva, Shpiro, Natalia, Ward, Richard, Cross, Darren, Ganley, Ian G., Alessi, Dario R.

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 3.30 MB

english, 2014

24

Influence of early discovery safety on eliminating off-target insulin receptor activity and selection of the candidate drug AZD9291

Anderton, Mark, Ward, Richard, Galer, Anne, Cross, Darren, Marks, Louise, Finlay, Ray

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 66 KB

english, 2014

25

[American Institute of Aeronautics and Astronautics 43rd AIAA Thermophysics Conference - New Orleans, Louisiana ()] 43rd AIAA Thermophysics Conference - Computational and Experimental Studies of Catalytic H2O2 Decomposition in Microscale Reactors

Widdis, Stephen, Hitt, Darren, Asante, Kofi, Cross, Michael, Varhue, Walter, McDevitt, Michael

Year:

2012

Language:

english

File:

PDF, 3.99 MB

english, 2012

26

Using phylogenetic diversity to identify ancient rain forest refugia and diversification zones in a biodiversity hotspot

Costion, Craig M., Edwards, Will, Ford, Andrew J., Metcalfe, Daniel J., Cross, Hugh B., Harrington, Mark G., Richardson, James E., Hilbert, David W., Lowe, Andrew J., Crayn, Darren M., Wilson, Kerrie

Journal:

Diversity and Distributions

Year:

2015

Language:

english

File:

PDF, 591 KB

english, 2015

27

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

Cross, Darren A. E., Culbert, Ainsley A., Chalmers, Katy A., Facci, Laura, Skaper, Stephen D., Reith, Alastair D.

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 695 KB

english, 2001

28

Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

Hennessy, Edward J, Chuaqui, Claudio, Ashton, Susan, Colclough, Nicola, Cross, Darren A. E., Debreczeni, Judit É., Eberlein, Cath, Gingipalli, Lakshmaiah, Klinowska, Teresa C. M., Orme, Jonathan P, Sh

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.22 MB

english, 2016

29

Biochemical characterisation of ATR protein kinase

Hall-Jackson, Clare A., Cross, Darren A. E., Jenkins, David M., Smythe, Carl

Journal:

Biochemical Society Transactions

Year:

1999

Language:

english

File:

PDF, 133 KB

english, 1999

30

ERK5 and the regulation of endothelial cell function

Roberts, Owain Llŷr, Holmes, Katherine, Müller, Jürgen, Cross, Darren A.E., Cross, Michael J.

Journal:

Biochemical Society Transactions

Year:

2009

Language:

english

File:

PDF, 180 KB

english, 2009

31

Shear stress, tip cells and regulators of endothelial migration

Zhuang, Xiaodong, Cross, Darren, Heath, Victoria L., Bicknell, Roy

Journal:

Biochemical Society Transactions

Year:

2011

Language:

english

File:

PDF, 236 KB

english, 2011

32

[IEEE 2016 IEEE International Parallel and Distributed Processing Symposium (IPDPS) - Chicago, IL, USA (2016.5.23-2016.5.27)] 2016 IEEE International Parallel and Distributed Processing Symposium (IPDPS) - Algorithm and Architecture Independent Benchmarking with SEAK

Tallent, Nathan R., Manzano, Joseph B., Gawande, Nitin A., Kang, Seunghwa, Kerbyson, Darren J., Hoisie, Adolfy, Cross, Joseph K.

Year:

2016

Language:

english

File:

PDF, 871 KB

english, 2016

33

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

Bago, Ruzica, Sommer, Eeva, Castel, Pau, Crafter, Claire, Bailey, Fiona P, Shpiro, Natalia, Baselga, José, Cross, Darren, Eyers, Patrick A, Alessi, Dario R

Journal:

The EMBO Journal

Year:

2016

Language:

english

File:

PDF, 49 KB

english, 2016

34

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

Bago, Ruzica, Sommer, Eeva, Castel, Pau, Crafter, Claire, Bailey, Fiona P, Shpiro, Natalia, Baselga, José, Cross, Darren, Eyers, Patrick A, Alessi, Dario R

Journal:

The EMBO Journal

Year:

2016

Language:

english

File:

PDF, 2.08 MB

english, 2016

35

SFK/FAK signaling attenuates osimertinib efficacy in both drug-sensitive and drug-resistant models of EGFR-mutant lung cancer

Ichihara, Eiki, Westover, David, Meador, Catherine B, Yan, Yingjun, Bauer, Joshua A., Lu, Pengcheng, Ye, Fei, Kulick, Amanda, De Stanchina, Elisa, McEwen, Robert, Ladanyi, Marc, Cross, Darren, Pao, Wi

Journal:

Cancer Research

Year:

2017

Language:

english

File:

PDF, 975 KB

english, 2017

36

The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M

Butterworth, Sam, Cross, Darren A. E., Finlay, M. Raymond V., Ward, Richard A., Waring, Michael J.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.84 MB

english, 2017

37

Targeting HER2 Aberrations in Non-Small Cell Lung Cancer with Osimertinib

Liu, Shengwu, Li, Shuai, Hai, Josephine, Wang, Xiaoen, Chen, Ting, Quinn, Max M., Gao, Peng, Zhang, Yanxi, Ji, Hongbin, Cross, Darren, Wong, Kwok-Kin

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 1.59 MB

english, 2018

38

Reactivation of mutant-EGFR degradation through clathrin inhibition overcomes resistance to EGFR tyrosine kinase inhibitors.

Ménard, Ludovic, Floc'h, Nicolas, Martin, Matthew J., Cross, Darren AE

Journal:

Cancer Research

Year:

2018

Language:

english

File:

PDF, 4.58 MB

english, 2018

39

The virome of Drosophila suzukii, an invasive pest of soft fruit

Medd, Nathan C, Fellous, Simon, Waldron, Fergal M, Xuéreb, Anne, Nakai, Madoka, Cross, Jerry V, Obbard, Darren J

Journal:

Virus Evolution

Year:

2018

Language:

english

File:

PDF, 1.83 MB

english, 2018

40

Plant DNA Barcodes Can Accurately Estimate Species Richness in Poorly Known Floras

Costion, Craig, Ford, Andrew, Cross, Hugh, Crayn, Darren, Harrington, Mark, Lowe, Andrew, Gilbert, Jack Anthony

Journal:

Year:

2011

Language:

english

File:

PDF, 384 KB

english, 2011

41

Cross-sectional study of area-level disadvantage and glycaemic-related risk in community health service users in the Southern.IML Research (SIMLR) cohort

Cross, Roger, Bonney, Andrew, Mayne, Darren J, Weston, Kathryn M

Journal:

Australian Health Review

Year:

2017

Language:

english

File:

PDF, 160 KB

english, 2017

42

Inhibition of oxidative phosphorylation suppresses the development of osimertinib resistance in a preclinical model of EGFR-driven lung adenocarcinoma

Martin, Matthew J., Eberlein, Cath, Taylor, Molly, Ashton, Susan, Robinson, David, Cross, Darren

Journal:

Year:

2016

Language:

english

File:

PDF, 9.00 MB

english, 2016

43

Inhibition of oxidative phosphorylation suppresses the development of osimertinib resistance in a preclinical model of EGFR-driven lung adenocarcinoma

Martin, Matthew J., Eberlein, Cath, Taylor, Molly, Ashton, Susan, Robinson, David, Cross, Darren

Journal:

Year:

2016

File:

PDF, 9.00 MB

2016

44

Osimertinib, an EGFR tyrosine kinase inhibitor, exerts anti-tumor activity in preclinical NSCLC models harboring the uncommon EGFR mutations G719X or L861Q or S768I

Floc'h, Nicolas, Lim, Sangbin, Bickerton, Sue, Ahmed, Afshan, Orme, Jonathan, Urosevic, Jelena, Martin, Matthew J., Cross, Darren AE, Cho, Byoung Chul, Smith, Paul D

Journal:

Molecular Cancer Therapeutics

Year:

2020

File:

PDF, 1.05 MB

2020